HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Isaka, Y. Articles by Abe, H. Search for Related Content PubMed PubMed Citation Articles by Isaka, Y. Articles by Abe, H.

Platelet Accumulation in Carotid Atherosclerotic Lesions: Semiquantitative Analysis with Indium-111 Platelets and Technetium-99m Human Serum Albumin

Osaka University Medical School, Fukushima, Osaka 553, Japan

Correspondence: For reprints contact: Yoshinari Isaka, MD, The Division of Nuclear Medicine, Osaka University Medical School, Fukushima, I chome, Fukushima-ku, Osaka 553, Japan.

ABSTRACT

To evaluate platelet accumulation in carotid atheroscierotic lesions semiquantitatively, a dual-tracer technique was applied, using in-111 platelets and Tc-99m human serum albumin. With this approach, we investigated the ratio of radioactivity in In-111 platelets deposited on the vascular wall to those circulating in the blood pool, platelet accumulation index (PAI). This study included 12 normal subjects and 25 patients with ischemic cerebrovascular disease (CVD). Angiographic abnormalities were observed at 34 of 50 carotid bifurcations in the CVD patients. The mean PAI value was significantly higher at the carotid bifurcations with angiographic abnormality than at the normal ones (p <0.001). Furthermore, elevations of mean PAI were prominent at the lesions with severe stenosis or ulceration. The degree of platelet accumulation was well demonstrated by this technique, which can also yield information on thrombogenicity and efficiency of antiplatelet therapy in carotid atherosclerotic disease.

This article has been cited by other articles:

				H. Moriwaki, M. Matsumoto, N. Handa, Y. Isaka, K. Hashikawa, N. Oku, M. Nakamura, T. Kamada, and T. Nishimura Functional and Anatomic Evaluation of Carotid Atherothrombosis : A Combined Study of Indium 111 Platelet Scintigraphy and B-Mode Ultrasonography Arterioscler. Thromb. Vasc. Biol., December 1, 1995; 15(12): 2234 - 2240. [Abstract] [Full Text]