HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Buell, U. Articles by Einhäupl, K. Search for Related Content PubMed PubMed Citation Articles by Buell, U. Articles by Einhäupl, K.

Dynamic SPECT with Xe-133: Regional Cerebral Blood Flow in Patients with Unilateral Cerebrovascular Disease: Concise Communication

Klinikum Grosshadern, University of Munich, Federal Republic of Germany

Correspondence: For reprints contact: Dr. U. Buell, Div. of Nucl. Med., Marchioninistr. 15, 8000 Munich 70, F R. G.

ABSTRACT

To validate xenon-133 dynamic single photon emission tomography (SPECT) clinically, 74 patients were examined. Strictly unilateral cerebrovascular disease was confirmed in 47 patients by clinical history and by transmission computerized tomography (TCT) and contrast angiography. Twenty-seven were excluded, considered normal. SPECT flow maps were evaluated visually (against TCT) or by automated region of interest (ROI) techniques (12 areas per slice) to measure area flow (AF) (ml/100 g-min) and interhemispherical area flow ratios (AR). These were compared with normal values. Minimum AF in affected hemisphere decreased, and AR-to-normal difference increased, with the severity of the disease. Visually, low-flow areas were detected twice as frequently in SPECT ad areas of low density in TCT. In reversible episodes, sensitivity of AF alone was significantly below the sensitivity of combined evaluation of flow and ratio.