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N,N'-bis(S-Benzoylmercaptoacetamido) Ethylenediamine and Propylenediamine Ligands as Renal Function Imaging Agents

I. Alternate Synthetic Methods

State University of New York, Syracuse, New York

Correspondence: For reprints contact: Richard F. Schneider, MD, Div. of Nucl. Med., Upstate Med. Ctr., 750 East Adams St., Syracuse, NY 13210.

ABSTRACT

A new method was developed to synthesize tetradentate ligands containing the N,N'-bis(S-benzoylmercaptoacetyl) ethylenediamine and propylenediamine moieties (DADS compounds). Methods are also represented with which to synthesize some of the positional isomers of the above compounds. These isomers represent a new class of compounds. A total of 21 different compounds were prepared. These will be used in an effort to establish a relationship between structure and renal imaging properties.