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Concentration of In-111-Oxine-Labeled Autologous Leukocytes in Noninfected and Nonrejecting Renal Allografts: Concise Communication

Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin

Correspondence: For reprints contact: B. David Collier, MD, Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Ave. Milwaukee, WI 53226.

ABSTRACT

Autologous leukocytes labeled with In-111 oxine (ILL) concentrated in the renal allografts of eight patients for whom transplant rejection, infection, or acute tubular necrosis (ATN) could be excluded. All patients had good-to-adequate renal function at the time of ILL scintigraphy, and none developed rejection or renal transplant failure during a 1-mo follow-up period. It is concluded that normally functioning renal allografts without evidence of rejection, infection, or ATN often will concentrate ILL. When a baseline study is not available for comparison, this phenomenon limits the value of ILL scintigraphy as a diagnostic test for transplant rejection or infection.