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Thallium-201 for Medical Use. Part 3: Human Distribution and Physical Imaging Properties

Brookhaven National Laboratory, Upton, New York
Donner Laboratory, University of California, Berkeley, California

Correspondence: For reprints contact: Harold L. Atkins, Brookhaven National Laboratory, Associated Universities, Inc., Upton, NY 11973.

ABSTRACT

Studies were undertaken to determine the biologic distribution of thallium-201 in man. The disappearance from the blood is extremely rapid and intracellular deposition is nearly immediate. The biologic half-time of thallium was measured by both the Brookhaven whole-body counter and the Donner whole-body scanner, with excellent agreement. The effective whole-body half-time of thallium-201 is about 57 hr. Concentration of activity was seen in the heart, kidneys, large bowel, and thyroid. The whole-body radiation dose is 0.21 rads/mCi.

FOOTNOTES

^* Present address: New England Nuclear Corp., North Billerica, MA 01862.