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Aromatic Radiofluorination with [¹⁸F]Fluorine Gas: 6-[¹⁸F]Fluoro-L-Dopa

McMaster University Medical Centre, Hamilton, Ontario, Canada

Correspondence: For reprints contact: Gunter Firnau, PhD, Dept. of Nuclear Medicine, McMaster University Medical Centre, 1200 Main St. W., Hamilton, Ontario, Canada, L8N 3Z5.

ABSTRACT

A new synthesis is described for the routine production of 3,4-dihydroxy-6-[¹⁸F]fluoro-phenyl-L-alanine (6-[¹⁸F]fluoro-L-dopa). The reaction between [¹⁸F]fluorine gas and 3,4-dihydroxyphenyl-L-alanine (L-dopa) in liquid hydrogen fluoride gave 2-, 5-, and 6-[¹⁸F]fluoro-L-dopa. 6-[¹⁸F]Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi [¹⁸F]F₂, the method produces 3 mCi of 6-[¹⁸F]fluoro-L-dopa at the end of synthesis.