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C-11 Dimethyloxazolidinedione (DMO): Biodistribution, Radiation Absorbed Dose, and Potential for PET Measurement of Regional Brain pH: Concise Communication

Memorial Sloan-Kettering Cancer Center, New York, New York

Correspondence: For reprints contact: K. J. Kearfott, ScD, Dept. of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021.

ABSTRACT

An improved radiochemical synthesis for C-11 dimethyloxazolidinedione (C-11 DMO) makes this agent attractive for the measurement of regional brain tissue pH (rpH) using positron emission tomography (PET). Toward this end, biodistribution data for C-14 DMO in rats at various times after an intravenous bolus injection are reported, together with estimates of radiation absorbed dose for C-11 DMO in man. An error analysis of C-11 DMO PET measurement of rpH indicates that rpH can be determined to within ±0.1 pH unit for pH >6.5 with a 20-mCi injected bolus of C-11 DMO, a 30–45-min equilibration time, and a 15-min PET imaging period.