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Repeatability of Estimates of Left-Ventricular Volume from Blood-Pool Counts: Concise Communication

Toronto General Hospital, Toronto, Ontario

Correspondence: For reprints contact: Dr. P. R. McLaughlin, Toronto General Hospital, Cardiovascular Unit, Eaton Bldg., 1st Floor, Rm. 424, 101 College St., Toronto, Ontario, M5G 1L7.

ABSTRACT

Radionuclide ventriculography permits nongeometric calculation of ventricular volume. Accurate and reproducible determination of left-ventricular (LV) blood-pool counts is necessary to perform this calculation. Furthermore, to make serial volume determinations one must know the half-time of in vivo blood-pool activity. We compared five methods of LV count determination in nine patients. Interpatient and intrapatient variability of the in vivo half-time of Tc-99m-labeled red blood cells (RBCs) was measured. Left-ventricular count determinations, derived from temporally and spatially smoothed images using a second-derivative algorithm to identify the LV region of interest (ROI), are less variable than those based on manual ROI determinations. The mean in vivo half-time of Tc-99m RBCs is 4.1 hr, and there is significant interpatient (0.9 ± 0.8 hr) and intrapatient (1.0 ± 0.9 hr) variability. These findings should be considered in the determination of serial, relative ventricular volume by radionuclide ventriculography.

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