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Labeling with Indium-111 has Detrimental Effects on Human Lymphocytes: Concise Communication

Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam
University Hospital Wilhelmina Gasthuis, Amsterdam
Sylvius Laboratory, State University of Leiden and J. A. Cohen Institute of Radiopathology and Radiation Protection, Leiden, The Netherlands

Correspondence: For reprints contact: R.J.M. ten Berge, c/o Publication Secretariat, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, PO Box 9406, 1006 AK Amsterdam, The Netherlands.

ABSTRACT

When lymphocytes from human peripheral blood were labeled with in-111 oxinate, several of their properties appeared to be affected. The spontaneous release of the radionuclide was found to be relatively high. Labeled lymphocytes showed a decreased proliferative capacity, dependent on the dose of the label. Cytogenetic studies revealed that in-111 oxinate induces severe chromosomal aberrations. These results emphasize the need for great caution in the use of the in-111 label for studies on lymphocyte traffic in humans.

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