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An On-Line Synthesis of [¹⁵O]N₂O: New Blood-Flow Tracer for PET Imaging

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

Correspondence: For reprints contact: Mirko Diksic, PhD, Medical Cyclotron Unit, Montreal Neurological Inst., McGill Univ., 3801 University St., Montreal, Quebec, Canada, H3A 2B4.

ABSTRACT

This paper describes a recently developed on-line synthesis of a new blood-flow tracer, O-15-labeled nitrous oxide. The tracer was produced by catalytic oxidation of anhydrous ammonia in a gas mixture containing O-15-labeled molecular oxygen. (The oxygen-15 was produced by a ¹⁴N(d,n)¹⁵O reaction.) Anhydrous ammonia was mixed with the gas containing [¹⁵O]O₂, and after preheating to about 200°C was carried through an oven containing a Pt catalyst kept at about 310°C. Labeled gas was purified in H₃PO₄ and KOH traps. O-15-labeled nitrous oxide was identified by gas radiochromatography and by various chemical reactions. Radiochemical purity of the O-15-labeled nitrous oxide exceeded 98%, radiochemical yield corrected for radioactioactive decay was 15–20%, and specific activity at the end of synthesis was about 50 mCi/mmole.