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A Ga-68-Labeled Tetrabromophthalein (Ga-68 BP-IDA) for Positron Imaging of Hepatobiliary Function: Concise Communication

Institute of Nuclear Medicine, German Cancer Research Center, Heidelberg, FRG

Correspondence: For reprints contact: Dr. Jochen Schuhmacher, Institute of Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, D-6900 Heidelberg.

ABSTRACT

We describe the chemical synthesis of an iminodiacetic-acid-substituted tetrabromo-o-cresolphthalein (BP-IDA), which complexes Ga-68 tightly. The liver uptake, bile excretion, and urinary excretion of the complex were examined in rats. Maximum liver uptake reached 60%, and 1-hr cumulative bile excretion was 75% on injected dose. Urinary excretion in rats with ligated common bile duct remained below 1%. Competitive action of exogenous bilirubin on hepatobiliary excretion of the Ga complex was less pronounced than that of bromosulfophthalein. The absolute activity determination of the positron emitter Ga-68, the high accumulation in the liver, the low urinary excretion, and the weak competition from exogenous bilirubin are promising features of this radiopharmaceutical for the quantitative study of hepatobiliary function.