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Thyroid Iodine Content Measured by X-Ray Fluorescence in Amiodarone-Induced Thyrotoxicosis: Concise Communication

Service de Médecine Nucléaire, Hopital de la Pitié Paris 75651 Cedex 13
Unité de Médecine Nucléaire, Institut Gustave Roussy Villejuif 94800, France

Correspondence: For reprints contact: Dr. Aubéne F. Léger, Service de Médecine Nucléaire, Hopital La Pitié, Paris 75651 Cedex 13, France.

ABSTRACT

Iodine-induced thyrotoxicosis (IIT) is characterized by (a) a low radioiodine uptake, increased by exogenous TSH, and (b) a spontaneous evolution towards cure within a few months. An hypothetical pathogenesis of IIT is an initial inflation in the stores of thyroid hormones during iodine excess, followed by their sudden discharge into the circulation. Thyroid iodine content was measured by fluorescent scanning in 10 patients with amiodarone-induced thyrotoxicosis and in various control groups. Results were found to be high at the onset of the disease and to decrease during its course. The data agree with the hypothetical pathogenesis. Furthermore they may permit exclusion of a painless subacute thyroiditis, which is the main differential diagnosis of IIT.

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