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Tc-99m Hydroxymethylene Diphosphonate and Tc-99m Methylene Diphosphonate: Biological and Clinical Comparison: Concise Communication

University of Washington, Seattle, Washington

Correspondence: For reprints contact: Thomas G. Rudd, MD, Harborview Medical Center, Depart. Of Radiology ZA-65, 325 9th Ave., Seattle, WA 98104.

ABSTRACT

The biologic and imaging characteristics of Tc-99m HMDP and Tc-99m MDP were compared in ten patients. Tc-99m HMDP blood levels were marginally lower at 4 hr. There were no significant differences in 4-hr urinary clearance, normal bone-to-background ratio, or ratio of lesion to normal bone. Relative image quality comparison showed a slight preference for Tc-99m MDP. Under the conditions of this study, Tc-99m HMDP image quality is at least comparable to that of Tc-m MDP.