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Pharmacologic Alterations in Tc-99m Binding by Red Blood Cells: Concise Communication

Albert Einstein College of Medicine, and Montefiore Medical Center, Bronx, New York

Correspondence: For reprints contact: J. P. Wexler, MD, PhD, Dept. of Nucl. Med.,Hospital of the Albert Einstein College of Medicine, 1825 Eastchester Road, Bronx, NY 10461.

ABSTRACT

The effect of two antihypertensive agents (captopril and prazosin) and of digoxin on the efficiency of Tc-99m binding to RBCs was evaluated in the rat. RBCs were labeled with Tc-99m in vivo in six groups of rats: l-normotensive controls Wistar rat (WR), II-prazosin treated WR, III-spontaneously hypertensive rat (SHR), IV-prazosin- treated SHR, V-digoxin-treated WR, and VI-captopril-treated WR. The percentageof intravascular Tc-99m bound to RBC ( %T) and the percentage of injected dose remaining intravascular 5 min after injection (%i.v.) were determined. Mean %T was 94.2, 83.8, 94.9, 86.1, 79.7, and 93.3 for groups I-VI respectively. Mean %I.V. was 96.4, 74.6, 94.9, 79.0, 74.4, and 87.4 for groups I-VI respectively. The findings demonstrate a significant reduction of RBC tagging with Tc-99m in rats treated with prazosin and digoxin but not with captopril. The data suggest a potential interference by patient medication with the performance of blood-pool studies.