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Scintigraphic Evaluation of Muscle Damage Following Extreme Exercise: Concise Communication

Roseville Community Hospital, and University of California, Davis, California

Correspondence: For reprints contact: Dr. Philip Matin, Sierra Nuclear Medical Group. PO Drawer 1185, Roseville, CA 95678.

ABSTRACT

Total body Tc-99m pyrophosphate scintigraphy was performed on 11 "ultramarathon" runners to assess the ability of nuclear medicine technique to evaluate skeletal-muscle injury due to exercise. We found increased muscle radionuclide concentration in 90% of the runners. The pattern of muscle uptake correlated with the regions of maximum pain. The detection of exercise-induced rhabdomyolysis appeared to be best when scintigraphy was performed within 48 hr after the race, and to be almost undetectable after about a week. It was possible to differentiate muscle injury from joint and osseous abnormalities such as bone infarct or stress fracture. Although 77% of the runners had elevated serum creatine kinase MB activity, cardiac scintigraphy showed no evidence of myocardial injury.