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Quantitative Biliary Dynamics: Introduction of a New Noninvasive Scintigraphic Technique

Veterans Administration Medical Center, and Oregon Health Sciences University, Portland, Oregon

Correspondence: For reprints contact: G. T. Krishnamurthy, VA Medical Center (115P), 3710 SW US Veterans Hospital Rd., Portland, OR 97201.

ABSTRACT

We used a Tc-99m-labeled hepatobillary agent to measure the partition of hepatic bile between gallbladder and intestine in sixteen normal patients and nine patients with choletithiasis. In normal subjects, the fractions of the hepatic bile that flow into the gallbladder and the small intestine were widely variable, with mean values of 69 ± 7% (s.e.) and 31 ± 7% respectively. Bile reflux into the common hepatic duct was rare, occurring during the first 2/3 of the gallbladder ejection period and only when the ejection fraction was greater than 59%. The gallbladder’s mean latent period, ejection period, ejection fraction, and ejection rate were 2 ± 1 min, 11 ± 1 min, 59 ± 4%, and 5.9%/min respectively. In patients with cholelithiasis, the fraction of hepatic bile flowing into the gallbladder was normal, but the ejection fraction was significantly reduced (p <0.005). For an equivalent dose of cholecystokinin, the gallbladder in cholelithiasis is less responsive than in normal subjects.

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