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Radiotoxicity of Thallium-201 in Mouse Testes: Inadequacy of Conventional Dosimetry

University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey
University of Massachusetts, Amherst, Massachusetts

Correspondence: For reprints contact: Dr. Dandamudi V. Rao, Dept. of Radiology; NJ Med. School, 100 Bergen St., Newark, NJ 07103.

ABSTRACT

When Tl-201 is concentrated in mouse testes, the low-energy Auger electrons following its electron-capture decay are found to be much more effective in causing loss of testicular weight and reduction of sperm heads than the energetic beta particles from similarly distributed Tl-204. These results are contrary to expectations based on conventional dosimetry of tissue-incorporated radionuclides, and point to possible underestimation of risks by the currently adopted dosimetric procedures, especially in the case of radionuclides decaying by electron capture an internal conversion.

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