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Regional Blood-Flow Measurement in Rabbit Soft-Tissue Tumor with Positron Imaging Using the C¹⁵O₂ Steady-State and Labeled Microspheres

Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: Dr. Gordon L. Brownell, Physics Research Laboratory, Massachusetts General Hospital, Fruit St., Boston, MA 02114.

ABSTRACT

The C¹⁵O₂ steady-state method, with tomographic measurement of H₂¹⁵O, has been used to measure blood flow in normal muscle tissue and a soft-tissue tumor (V2) in rabbits. The method has been validated in a rabbit tumor model by comparison of the data with that observed using microspheres labeled with Sc-46 and Ga-68. The blood-flow values found with the C¹⁵O₂ steady-state method, after correction for tissue blood volume, agree well with values gained with labeled microspheres. The effect of blood volume on apparent blood flow in tumor was about 50%. The tissue/blood partition coefficients were 0.94 ± 0.05 for healthy tissue and 1.16 ± 0.15 for tumor tissue. After correction for partition coefficient and blood-volume effects, the blood-flow value for normal tissue was 4.1 ± 1.3 ml/min-100 cc, and for the tumor tissue 10.7 ± ml/min-100 cc.

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