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Tc-99m-Labeled Polystyrene and Cellulose Macromolecules: Agents for Gastrointestinal Scintigraphy

University of Illinois at Urbana-Champaign, Urbana, Illinois
Wichita State University, Wichita, Kansas

Correspondence: For reprints contact: Michael C. Theodorakis, Sect. of Nuclear Medicine, Dept. of Bioengineering, Univ. of Illinois at Urbana-Champaign, Urbana, IL 61801.

ABSTRACT

Several polystyrene resin and cellulose derivatives were evaluated for potential use as Tc-99m-labeled particulate markers for studies of gastric emptying and intestinal transit time, and for imaging segments of the gastrointestinal tract. The polyamine and quaternary ammonium polystyrene resins bound pertechnetate (Tc-99m) anions effectively; the labeling efficiency was over 95% at physiological pH values. In-vitro stability studies of Tc-99m-labeled resins in simulated gastric and intestinal fluid showed that less than 8% of the label was released after 24 hr. The commercial resins Dowex 2-X8, AG 1-X2, and Bio-Rex 9, labeled with Tc-99m, may be used as particulate markers of solid digesta in external scintigraphic studies of the gastrointestinal tract. Dowex 2-X8 showed relatively more extensive uptake of pertechnetate and greater stability in simulated gastric and intestinal fluids.