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Disparate Effects of Heparin on Free Thyroxine as Measured by Two Radioimmunoassays: Concise Communication

Stanford University School of Medicine, Stanford, California

Correspondence: For reprints contact: I. R. McDougall, MB, PhD, Div. of Nuclear Medicine, Stanford Univ. School of Medicine, Stanford, CA 94305.

ABSTRACT

Free thyroxine (FT₄) has been measured in two groups of patients, before and after heparin, using equilibrium dialysis (ED) and two radioimmunoassays, RIA-I and RIA-II. In Group A, nine patients were tested before and after 12–24 hr of intravenous heparin. FT₄ (ED) rose from 1.9 ± 0.5 to 2.8 ± 3.0 ng/dl, and RIA-I from 1.37 ± 0.37 to 1.89 ± 1.21 ng/dl, whereas RIA-II results fell from 0.97 ± 0.38 to 0.66 ± 0.32 ng/dl. In Group B, ten patients were tested before and after 15 min of intravenous heparin. FT₄ (ED) rose from 1.7 ± 0.7 to 3.2 ± 1.6 ng/dl (P < 0.02), and RIA-I rose from 1.3 ± 0.46 to 2.02 ± 1.01 ng/dl (P < 0.05), whereas RIA-II results fell from 1.07 ± 0.38 to 0.63 ± 0.31 ng/dl (P < 0.02). The correlation coefficient between FT₄ (ED) and RIA-I in 38 paired results was 0.96, but there was no correlation between FT₄ (ED) and RIA-II results.

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