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In Vivo Regional Quantitation of Intrathoracic Tc-99m using SPECT: Concise Communication

Duke University Medical Center, Durham, North Carolina

Correspondence: For reprints contact: Dr. Dennis Osborne, Box 3808, Dept. of Radiology, Duke University Medical Center, Durham, NC 27710.

ABSTRACT

A whole-body single-photon emission computed tomographic system (SPECT) was used to quantitate the activities of a series of Tc-99m point sources in the dog's thorax and to evaluate attenuation of a uniform esophageal line source containing a known concentration of Tc-99m.

A first-order attenuation correction and an empirically derived attenuation coefficient of 0.09 cm^–1 were used in the SPECT analyses of the intrathoracic point sources. The relationship between SPECT measurements of multiple point-source activities and the same sources measured in air was linear over a range of 100 to 1000 µCi (slope 1.08; R² coefficient of determination 0.97). These data are sufficiently accurate to allow an estimate of the regional activity of radiopharmaceutical in the dog's thorax and justify their use in experimental quantitation of regional pulmonary perfusion.