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Clinical Comparison of Tc-99m N,N'-Bis(mercaptoacetamido)ethylenediamine and [¹³¹I]ortho-iodohippurate for Evaluation of Renal Tubular Function: Concise Communication

University of Colorado Health Sciences Center, Denver, Colorado

Correspondence: For reprints contact: W. C. Klingensmith, III, MD, Division of Nuclear Medicine, U. of Colorado Health Sciences Center, Denver, CO 80262.

ABSTRACT

Recent experiments in normal animals have shown that Tc-99m N,N'-bis(mercaptoacetamido)ethylenediamine (Tc-99m DADS) is a potential technetium-99m-labeled replacement for [¹³¹I]ortho-iodohippurate(I-131 Hipp). We compared the two agents in eleven patients with renal transplants (serum creatinine range: 0.9–5.7 mg/dl). Digital and analog images were recorded for 30 min and after voiding. The results indicate that the relative extraction efficiency index of Tc-99m DADS is 76% ± 3 (mean ± s.e.m.), that the leading-edge parenchymal transit time of Tc-99m DADS is 137% ± 6, and that the percentage of injected Tc-99m DADS in the bladder at 30 min is 25% ± 4 of that of I-131 Hipp (all p < 0.05). Forty percent of patients showed some hepatoblliary excretion of Tc-99m DADS. We conclude that the biologic properties of Tc-99m DADS are inferior to those of I-131 Hipp and that analogs of Tc-99m DADS should be evaluated in an attempt to find a more suitable technetium-99m-labeled replacement for I-131 Hipp.