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Use of Functional Maps in Renal Scintigraphy to Detect Segmental Arterial Lesions

National Institutes of Health, Bethesda, Maryland

Correspondence: For reprints contact: A. Eric Jones, MD, Dept. of Nuclear Medicine, Bldg. 10, Room 1B 38B, National Institutes of Health, Bethesda, MD 20205.

ABSTRACT

Renography using a gamma camera, a minicomputer, [¹²³I]orthoiodohippurate ([¹²³I]OIH), and a canine model was employed to evaluate computer-generated maps of regional renal function. Renograms were obtained before and after ligations of the right renal arterial branch in four dogs, with subsequent angiographic and histologic confirmation of the lesions. Postoperative time-activity curves were normal. Washout and persistence index in three of four right kidneys showed regional abnormality. Functional renal mapping may provide a clinical technique for evaluating human renal vascular hypertension.