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Effect of Endotoxin Fever on Plasma Clearance of Thyroxine and Tri-iodothyronine: Concise Communication

VA Medical Center and University of Minnesota, Minneapolis, Minnesota

Correspondence: For reprints contact: Dr. Shafer, Nuclear Medicine Service (115), VA Medical Center, 54th St. and 48th Ave. So., Minneapolis, MN 55417

ABSTRACT

Endotoxin-induced fever in rabbits causes a rapid decrease in serum T₃, a reciprocal rise of 3,3',5'-tri-iodothyronine (rT₃), and a less marked reduction in T₄ with a rebound at 24 hr. To answer the question whether the alteration in hormone levels was the result of a decrease in T₃ or T₄ production and release or of an increase in T₃ and T₄ metabolism, we measured the disappearance of [¹²⁵I]T₄ and [¹²⁵I]T₃ during endotoxin-induced fever and externally applied heat. Results showed no significant difference in disappearance of [¹²⁵I]T₄ or [¹²⁵I]T₃. This suggests that the rapid change in T₃ levels associated with endotoxin fever is due to an inhibition of thyroid production and peripheral conversion, and not to increased metabolism of hormones.

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