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Bone and Bone-Marrow Blood Flow in Chronic Granulocytic Leukemia and Primary Myelofibrosis

Kuopio University Central Hospital and University of Kuopio, Kuopio, Finland

Correspondence: For reprints contact: Tapani Lahtinen, PhD, Dept. of Clinical Physiology, Kuopio Univ. Central Hospital, SF-70210 Kuopio 21, Finland.

ABSTRACT

Blood flow in hematopoietic bone marrow and in nonhematopoietic bone has been measured with a Xe-133 washout method in 20 patients with chronic granulocytic leukemia (CGL) and in seven with primary myelofibrosis. Age-matched healthy persons served as controls. Bone-marrow blood flow in CGL was dependent upon the phase of the disease. In the metamorphosis phase, bone-marrow blood flow was high compared with that in the well-controlled phase. Apart from the initial phase, the mean values for bone blood flow in CGL were increased compared with the values of the healthy controls. In myelofibrosis the bone blood flow was also increased.

one-marrow blood flow in these diseases was dependent upon the cellularity of bone marrow as measured morphometrically.