HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soundy, R. G. Articles by Merrick, M. V. Search for Related Content PubMed PubMed Citation Articles by Soundy, R. G. Articles by Merrick, M. V.

Absorbed Dose to Man from the Se-75 Labeled Conjugated Bile Salt SeHCAT: Concise Communication

Amersham International Limited, Amersham, Bucks, England
The Western General Hospital, Edinburgh, Scotland

Correspondence: For reprints contact: M. V. Merrick, Medical Radioisotope Dept., Western General Hospital, Crewe Rd., Edinburgh EH4 2XU, Scotland.

ABSTRACT

The absorbed radiation dose that would result from the oral or intravenous administration of SeHCAT (23-[⁷⁵Se]selena-25-homotaurocholate) has been calculated using the MIRD tables and formulas and data from measurements of whole-body distribution and from long-term whole-body counting in rats, mice, and man. When SeHCAT is administered to normal subjects, the gallbladder is the critical organ, receiving 12 mrad (oral dose) or 22 mrad (i.v.) per microcurie. The whole-body dose is 1 mrad/µCi, whatever the route of administration. In severe hepatic failure the liver might receive 200 mrad/µCi. The activity likely to be used in routine clinical practice is 10 µCi. Where a whole-body counter is used, an activity of 1 µCi has proved adequate. Even at an administered activity of 25 µCi, the absorbed dose is small compared with established techniques of investigating the gastrointestinal tract.

This article has been cited by other articles:

				A Lanzini, M G De Tavonatti, B Panarotto, S Scalia, A Mora, F Benini, O Baisini, and F Lanzarotto Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration Gut, September 1, 2003; 52(9): 1371 - 1375. [Abstract] [Full Text]