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Effect of Antiarrhythmic Drugs on In-111-Labeled Leukocytes: Chemotaxis and Adherence to Nylon Wool

Yale University School of Medicine, New Haven, Connecticut

Correspondence: For reprints contact: M. L. Thakur, PhD, Dept. of Diagnostic Radiology, Yale Univ. School of Medicine, 333 Cedar St., New Haven, CT 06510.

ABSTRACT

The influence of lidocaine (L) and procainamide (P) on the chemotactic ability and adherence to nylon wool of In-111-labeled human polymorphonuclear leukocytes (PMNs)was investigated. At the normal therapeutic levels of L (0.022 mM whole blood) or P (0.03 mM whole blood) no change in PMN function was observed. However, at and above five times the aforementioned blood levels of L, significant reduction in the chemotactic ability of PMNs was noted (P < 0.005). The adverse effects of In-111 radiation appeared insignificant at all L or P concentrations during the 3-hr observation period. The labeled PMNs were resistant to the toxic effects of a higher concentration of P than that of L, and the reduction in PMN chemotaxis and adherence to nylon wool was not apparent until the P concentration reached 1.5 mM.