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Incidence of Hypothyroidism Occurring Long after Iodine-131 Therapy for Hyperthyroidism

Karolinska Hospital, Stockholm, Sweden

Correspondence: For reprints contact: L.-E. Holm, Dept. of General Oncology, Radiumhemmet, Karolinska Hospital, S-104 01 Stockholm, Sweden.

ABSTRACT

We have studied the long-term incidence of hypothyroidism in 4,473 formerly hyperthyroid patients given I-131 therapy between 1951 and 1975. The mean age at the first I-131 treatment was 56 yr. Six percent developed hypothyroidism within one year of therapy, and 72% within 26 yr. Prior antithyroid medication did not affect the incidence of hypothyroidism. Patients cured with one dose of I-131 had a lower cumulative long-term incidence of hypothyroidism than those requiring more than one dose.

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