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Difluoromethylomithine Enhancement of Putrescine Uptake into the Prostate: Concise Communication

Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Dr. Dov Kadmon, Washington Univ. Med. School, Div. of Urol., 4960 Audubon Ave., St. Louis, MO 63110.

ABSTRACT

We studied the effect of alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, on putrescine uptake by the rat prostate. Using C-14 putrescine, we found a several-fold increase in uptake by both the dorsal and ventral prostates of DFMO-pretreated intact animals, compared with untreated controls. When previously castrated animals were treated with a combination of testosterone and DFMO, the prostatic uptake of exogenously administered C-14 putrescine increased more than tenfold. Under these condition, DFMO enhanced the uptake by the prostate to a greater extent than by any other tissue studied.