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Cellular Basis for Accumulation of In-111-Labeled Leukocytes and Platelets in Rejecting Cardiac Allografts: Concise Communication

College of Physicians & Surgeons, Columbia University, New York, New York

Correspondence: For reprints contact: Theodore S. T. Wang, PhD, Div. Nucl. Med., Columbia-Presbyterian Medical Center, 622 West 168 St., New York, NY 10032.

ABSTRACT

Biodistribution and imaging studies in rats showed that In-111-labeled leukocytes and platelets accumulate progressively with time after transplantation in cardiac allografts undergoing rejection, but do not accumulate in normal syngeneic heart grafts. Maximum heart allograft-to-blood ratios of 9:1 were obtained, and allograft-to-native heart ratios of 17:1. Microscopic studies of the rejecting cardiac allografts showed that histologic findings paralleled the cellular changes predicted by the radionuclide studies. Intravenously administered Ga-67 citrate and Tc-99m sulfur colloid failed to show significant accumulation in rejecting grafts. The findings suggest that cellular rejection, rather than nonspecific inflammatory changes, is the primary basis for accumulation of In-111 leukocytes and platelets in rejecting cardiac allografts.