HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Henze, E. Articles by Bennett, L. R. Search for Related Content PubMed PubMed Citation Articles by Henze, E. Articles by Bennett, L. R.

Lymphoscintigraphy with Tc-99m-Labeled Dextran

UCLA School of Medicine, University of California at Los Angeles, Los Angeles, California

Correspondence: For reprints contact: Eberhard Henze, MD, UCLA School of Medicine, Laboratory of Nuclear Medicine, Los Angeles, CA 90024.

ABSTRACT

Current agents for lymphoscintigraphy have limitations because of slow migration of the colloidal tracers from the injection site and the unknown effect of phagocytosis on the removal of the labeled particles. The usefulness of Tc-99m dextran (TcDx) with a molecular weight of 110,000 has been tested for lymphoscintigraphy. Computer-assisted dynamic imaging and serial blood sampling in 13 dog experiments demonstrated that the tracer cleared only by lymph drainage from an interstitial injection site. Following interdigital injection of 1.0 ml (0.5–5.0 mCl), TcDx reached the knee or elbow lymph nodes in 12.4 ± 6.5 (1 s.d.) sec, and the inguinal or axillary lymph nodes in 98.0 ± 42.3 sec. It cleared from the injection site with a half-time of 31.5 min. In a dog with surgically induced lymphedema, tracer migration was markedly delayed in the edematous leg and the radionuclide lymphoscintigram resembled the contrast lymphangiogram. Initial studies in man yielded high-quality radionuclide lymphograms of the leg, and the pelvic and para-aortic lymph nodes. We conclude that TcDx is very promising for lymphoscintigraphy.

This article has been cited by other articles:

				F. L. Connor, S. Angelides, M. Gibson, D. W. Larden, M. R. Roman, O. Jones, B. G. Currie, A. S. Day, and T. D. Bohane Successful Resection of Localized Intestinal Lymphangiectasia Post-Fontan: Role of 99mTechnetium-Dextran Scintigraphy Pediatrics, September 1, 2003; 112(3): e242 - 247. [Abstract] [Full Text] [PDF]

				A. Szuba, W. S. Shin, H. W. Strauss, and S. Rockson The Third Circulation: Radionuclide Lymphoscintigraphy in the Evaluation of Lymphedema J. Nucl. Med., January 1, 2003; 44(1): 43 - 57. [Abstract] [Full Text] [PDF]

				J. R. Sanders, N. A. Pou, and R. J. Roselli Neutral and DEAE dextrans as tracers for assessing lung microvascular barrier permeability and integrity J Appl Physiol, July 1, 2002; 93(1): 251 - 262. [Abstract] [Full Text] [PDF]

				G. Mariani, L. Moresco, G. Viale, G. Villa, M. Bagnasco, G. Canavese, J. Buscombe, H. W. Strauss, and G. Paganelli Radioguided Sentinel Lymph Node Biopsy in Breast Cancer Surgery J. Nucl. Med., August 1, 2001; 42(8): 1198 - 1215. [Abstract] [Full Text] [PDF]

				C. Tsopelas Particle Size Analysis of 99mTc-Labeled and Unlabeled Antimony Trisulfide and Rhenium Sulfide Colloids Intended for Lymphoscintigraphic Application J. Nucl. Med., March 1, 2001; 42(3): 460 - 466. [Abstract] [Full Text]

				M.K. Nawaz, M.M. Hamad, H.M. Abdel-Dayem, S. Sadek, and B.G.H. Eklof Lymphoscintigraphy in Lymphedema of the Lower Limbs Using 99mTc HSA Angiology, February 1, 1992; 43(2): 147 - 154. [Abstract] [PDF]