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Sensitivity of Kr-81m and Xe-127 in Evaluating Nonembolic Pulmonary Disease

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Herbert Susskind, PE, Medical Dept., Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

The relative sensitivities of Kr-81m and Xe-127 in detecting lung ventilation defects was evaluated in 80 patients with nonembolic pulmonary diseases. Krypton-81m ventilation images (500,000 count) were interdigitated with Tc-99m MAA perfusion images; both were compared with Xe-127 images. The distributions of the two gases were also compared on the basis of point-by-point computer analyses. Xenon-127 was found to be more sensitive than Kr-81m in clinical evaluations of scintiphotos—although they were equivalent by computer analyses—in indicating regions of impaired ventilation in patients with obstructive airways disease.