HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by de Kieviet, W. Search for Related Content PubMed PubMed Citation Articles by de Kieviet, W.

Technetium Radiopharmaceuticals: Chemical Characterization and Tissue Distribution of Tc-Glucoheptonate Using Tc-99m and Carrier Tc-99

Rotterdamsch Radio-Therapeutisch Instituut, Rotterdam, The Netherlands

Correspondence: For reprints contact: Wim de Kieviet, PhD, Dept. of Nuclear Medicine, Rotterdamsch Radio-Therapeutisch Instituut, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands.

ABSTRACT

The chemical structure of the kidney- and brain-imaging agent Tc-99m glucoheptonate has been established using the Tc-99 isotope. In a comparative study between Tc-99 and Tc-99m glucoheptonates, chromatographic, electrophoretic, and tissue distribution studies showed identical compounds in 0.9% NaCl. Optimal conditions for the formation of the Tc-99 glucoheptonate complex were investigated by uv and visible spectroscopy. The oxidation state of Tc-99 in the compound is V, measured by Sn²⁺ titration. The complex contains a Tc = O core and two glucoheptonate ligands (oxobis(glucoheptonato)technetate(V) anion (net charge: –1) in aqueous solution). NMR studies demonstrated two five-membered glucoheptonate rings, bidentate bound to Tc by the oxygens of the end carboxyl group and the adjacent hydroxyl group. The compound is stabilized by interaction between Tc-99 and one of the hydroxyloxygens of glucoheptonate at the vacant coordination site trans to the Tc = O core. Experiments with the reducing agent NaBH₄ demonstrated the absence of Sn (II or IV) in the complex and a biological behavior independent of the reducing agent used.