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The Effect of Gastrointestinal Hormones on the Pertechnetate Imaging of Ectopic Gastric Mucosa in Experimental Meckel's Diverticulum

Children's Hospital and Ohio State University College of Medicine, Columbus, Ohio

Correspondence: For reprints contact: G. N. Sfakianakis, MD, Div. of Nuclear Medicine (D-57), Univ. of Miami School of Medicine, P. O. Box 016960, Miami, FL 33101.

ABSTRACT

Meckel's diverticula were simulated in 12 dogs by implanting vascularized patches of gastric wall onto Roux-en-Y loops of distal ileum. All animals had camera imaging studies every 10 min for 60 min, with computer acquisition (1-min frames) following intravenous injection of 2 mCi of pertechnetate. The scintigrams were repeated following (a) subcutaneous injection of pentagastrin (6 µg/kg) 15 min before injection of pertechnetate; (b) intravenous injection of glucagon (50 µg/kg) 10 min after the tracer injection; (c) pretreatment with pentagastrin plus glucagon as above; and (d) pretreatment with pentagastrin plus secretin (1 unit Boots/kg intravenously 10 min after the pertechnetate). Patches of ectopic gastric mucosa as small as 1 cm² were visualized. Pentagastrin alone accelerated accumulation of the tracer but resulted in a decrease in the target-to-background ratio. Glucagon alone enhanced late gastric mucosal activity by preventing washout of the intraluminal activity. The combination of pentagastrin and glucagon enhanced visualization and kept background activity lowest. These findings indicate a potential role for glucagon in the diagnosis of ectopic gastric mucosa in humans.

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