HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Der, M. Articles by Bowen, B. M. Search for Related Content PubMed PubMed Citation Articles by Der, M. Articles by Bowen, B. M.

Decomposition of Tc-99m Pyrophosphate by Peroxides in Pertechnetate Used in Preparation

Chedoke-McMaster Hospital, Hamilton, Ontario, Canada

Correspondence: For reprints contact: B. M. Bowen, M.Sc.Phm. Dept. of Nuclear Medicine, Chedoke-McMaster Hospital, P.O. Box 2000, Station A, Hamilton, Ontario, Canada L8N 3Z5.

ABSTRACT

We describe an investigation of the stability of Tc-99m pyrophosphate (Tc-99m PPi). We have shown that addition of exogenous hydrogen peroxide to Tc-99m PPi can initiate the oxidation of the complex, giving rise to 95% unbound pertechnetate. The presence of endogenous hydrogen peroxide in the sodium pertechnetate used in the preparation of Tc-99m PPi has been thought to influence its stability. We have prepared it using pertechnetate solutions of different specific activities. After preparation, an alumina column was used to detect free ^99mTcO₄^–. The Tc-99m PPI and Na^99mTcO₄ solutions were then assayed by iodometric titration for hydrogen peroxide, which was detected in the pertechnetate solutions. The higher the specific activity of the solution used for the tracer preparation, the faster was the production of free pertechnetate.