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Radioiodinated Fatty Acids for Myocardial Imaging: Effects of Chain Length

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: Charlotte A. Otto, PhD, Div. of Nuclear Medicine, Univ. of Michigan Medical School, 3052 Kresge II, Ann Arbor, MI 48109.

ABSTRACT

Terminally iodinated long-chain fatty acids have been used experimentally and clinically as myocardial imaging agents. Six -iodo fatty acids (I(CH₂)_nCO₂H, where n = 10, 12, 15, 18, 21, 26) have been synthesized and tested in rats. Myocardial extraction values and head-to-blood ratios are affected by chain length. Extraction is shown to be highest for n = 18 and 21, as are heart-to-blood ratios at 5 min. The cellular fate of the fatty acid changes from that of ß-oxidation for n 15 to predominantly triglyceride storage for n = 18 and 21, as shown by analysis of rat heart homogenates by thin layer chromatography at two time intervals.