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The Use of Technetium-99m Sulfur Colloid as a Marker for Experimental Venous Thrombosis: Concise Communication

The Mount Sinai Medical Center, New York, New York

Correspondence: For reprints contact: Philip A. Bardfeld, MD, Div. of Nuclear Medicine, Nassau County Medical Center, East Meadow, NY 11554.

ABSTRACT

The binding of technetium-99m sulfur colloid to in vivo thrombi was studied in a rat model of deep vein thrombosis. After thrombosis was Induced by mechanical traumatization of a right femoral vein segment, technetium-99m sulfur colloid was injected into the peripheral veins of different experimental groups at intervals of 30 min and 1–7 days. Ratios of mean activity in traumatized right femoral vein segment to activity in control segments of left femoral vein (R/L ratios) ranged from 2.97–11.0 for all in situ venous thrombi studied. There was no relation between clot size and R/L ratios. The significant uptake ratios observed by us for venous thrombi up to 1 wk in age suggest that in vivo thrombus detection may be feasible by imaging with a gamma camera after technetium-99m sulfur colloid injection in a peripheral vein.