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University of Virginia Medical Center, Charlottesville, Virginia
Correspondence: For reprints contact: Denny D. Watson, PhD, Div. of Nuclear Imaging, Univ. of Virginia Medical Center, Box 468, Charlottesville, VA 22908.
ABSTRACT
A computer method has been developed to determine the relative initial uptake and segmental washout rates of thallium-201 from sequential myocardial images. Initial images in multiple projections are obtained at 10 min after thallium-201 injection, and delayed images 2–3 hr after injection. A modified interpolative method was used to construct a background reference plane, and net myocardial counts above this reference plane were determined from multiple count profiles. Washout rates were determined by linear regression of time-activity curves constructed from the sequential images. In this approach, both relative temporal as well as relatives spatial quantitation is performed. Data from 25 normal subjects were used to establish numerical criteria and normal ranges for relative focal defects and abnormal segmental washout slopes. Normal ranges were set to include the 90-percentile limits of the distribution of values obtained from the normal population. From these values we derived a quantitative criterion for thallium scan interpretation that can be used for analysis and interpretation of scintigrams in clinical situations.
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