HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fowler, J. S. Articles by Ruth, T. J. Search for Related Content PubMed PubMed Citation Articles by Fowler, J. S. Articles by Ruth, T. J.

A Shielded Synthesis System for Production of 2-Deoxy-2-[¹⁸F]Fluoro-D-Glucose

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Joanna S. Fowler, Dept. of Chemistry, Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

A remotely operated, shielded synthesis system for the production of 2-deoxy-2-[¹⁸F]fluoro-D-glucose (¹⁸FDG) for clinical studies has been developed. Using this system, 25 mCi of ¹⁸FDG are produced at the end of a 60-min synthesis from 300 mCi of F-18 (total F-18 recovered from the target at the end of bombardment). The fractional distribution of F-18 among various components of the synthesis system has been measured. This yield of ¹⁸FDG (25 mCi) is ample for two consecutive human studies in house or for shipment to collaborating institutions within a 3-hr (door to door) radius.

This article has been cited by other articles:

				Y Yonekura, A. Brill, P Som, K Yamamoto, S. Srivastava, J Iwai, D. Elmaleh, E Livni, H. Strauss, M. Goodman, et al. Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement Science, March 22, 1985; 227(4693): 1494 - 1496. [Abstract] [PDF]