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Remote, Semiautomated Production of F-18-Labeled 2-Deoxy-2-Fluoro-D-Glucose

University of California at Los Angeles School of Medicine and Laboratory of Nuclear Medicine and Radiation Biology, Los Angeles, California

Correspondence: For reprints contact: J. R. Barrio, PhD, Div. of Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA 90024.

ABSTRACT

A routine production system for 2-deoxy-2-[¹⁸F]fluoro-D-glucose (2-¹⁸FDG) for medical use is presented. The method involves the preparation of F-18-labeled F₂ by the ²⁰Ne(d,)¹⁸F reaction, subsequent fluorination of 3,4,6-tri-o-acetyl-D-glucal, purification, and hydrolysis of the appropriate diastereoisomer to obtain 2-¹⁸FDG. These operations are performed using a completely remote, semiautomatic system. There have been no failures in more than 220 consecutive production runs. Currently, two preparations per day of 15–25 mCi of 2-¹⁸FDG are routinely performed, with a radiochemical purity, measured by TLC, in excess of 95% and with less than 1 mR radiation exposure to the chemist. Reaction conditions, operational variables, and systems are described in detail.

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