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Imaging the Primate Adrenal Medulla with [¹²³I] and [¹³¹I] Meta-Iodobenzylguanidine: Concise Communication

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: Donald M. Wieland, PhD, Univ. of Michigan Hospital, 3685 Kresge I, Ann Arbor, MI 48109.

ABSTRACT

An evaluation of radioiodinated meta-iodobenzylguanidine (m-IBG) as an adrenomedullary imaging agent is reported in 15 rhesus monkeys. Scintiscans of the monkey adrenal medulla have been obtained with [¹²³I]- and [m-¹³¹I]IBG at 2–6 days after injection. The imaging superiority of m-IBG over its positional isomer, para-iodobenzylguanidine (p-IBG), is documented in both dogs and monkeys. Administration of reserpine, a depletor of catecholamine stores, markedly lowers the [m-¹³¹I]-IBG content of the dog adrenal medulla, but the adrenergic blocking agents phenoxybenzamine and propranolol have no effect. Subcellular fractionation of the dog's adrenal medullae reveals that m-IBG is sequestered mainly in the chromaffin storage granules. The results of this study suggest that radioiodinated m-IBG, previously reported to image the primate myocardium, also merits evaluation as a clinical radiopharmaceutical for the adrenal medulla.

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