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Calculation of Viable and Infarcted Myocardial Mass from Thallium-201 Tomograms

University of Michigan Medical School, Ann Arbor, Michigan

Correspondence: For reprints contact: John W. Keyes, Jr., MD, Div. of Nuclear Medicine, Univ. of Michigan Medical Ctr., Box 21, Ann Arbor, MI 48109.

ABSTRACT

The feasibility of determining the mass of both viable and infarcted myocardium from tomographic images of thallium-201 distribution in the heart was studied in two normal dogs and ten dogs with acute infarction. Twenty-four hours after occlusion, thallium-201 was injected and 10 min later the hearts were removed and transaxial emission computed tomograms were obtained. Using the computer, an operator defined the epi- and endocardial surfaces of the left ventricle and the area of infarction in each tomogram. The computer then calculated values for total left-ventricular mass (TLVM) infarcted mass (IM) and the percentage of the left ventricle infarcted (% LVI). The calculated values were compared with measured weights, and good correlation was found between them: for TLVM, r = 0.87; for IM, r = 0.90; and for %LVI, r = 0.87. Good interobserver and intra-observer correlations were also found. Thallium-201 emission computed tomography offers a potential means to measure both myocardial mass and acute myocardial injury.

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