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The Journal of Nuclear Medicine Vol. 22 No. 3 253-257
© 1981 by Society of Nuclear Medicine
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Imaging of Experimental Myocardial Infarction with Technetium-99m 2,3-Dimercaptosuccinic Acid

Ronald P. Karlsberg, Norah Milne, Kenneth P. Lyons and Wilbert S. Aronow

Veterans Administration Medical Center, Long Beach
University of California, Irvine, California

Correspondence: For reprints contact: Ronald P. Karlsberg, MD, Chief, Cardiovascular Physiology, 5901 E. 7th St., Long Beach, CA 90822.

ABSTRACT

We have studied the use of Tc-99m-labeled 2,3-dimercaptosuccinic acid (Tc-99m DMSA) to scintigraph acute myocardial infarction after coronary occlusion in dogs. Optimal images were obtained 5 hr after injection of radiotracer, with consistent delineation 48 hr after occlusion. Delivery of tracer was dependent on blood flow. Uptake of tracer correlated to extent of infarction as determined by the myocardial depletion of creatine kinase. Myocardial Tc-99m DMSA was protein-bound.






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Copyright © 1981 by the Society of Nuclear Medicine.