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F-18-Labeled 3-Deoxy-3-Fluoro-D-Glucose for the Study of Regional Metabolism in the Brain and Heart

Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: David R. Elmalch, Physics Research Lab., Massachusetts General Hospital, Boston, MA 02114.

ABSTRACT

Glucose is the major physiological substrate of the brain and an important physiological substrate for the myocardium. [¹⁸F]fluoro-3-deoxy-glucose [3-FDG(F-18)] was studied to determine whether it is a suitable tracer for evaluating the metabolic function of the brain and myocardium. 3-FDG(F-18) was rapidly accumulated in the mouse myocardium (10–12% injected dose/g) and remained constant up to 120 mm. Blood, liver, and lung activities exhibited a rapid accumulation of activity (4% injected dose/g) at 1 min, followed by elimination of activity up to 30 min (2% injected dose/g), and then remaining unchanged for a period of 120 min. The arterial blood curve in the dog was fit best by three exponential components (T_1/2 = 0.52 min, 2.75 min, and 142.8 min). Transverse-section images were obtained of the dog's brain and myocardium. From sequential two-dimensional images, a clearance half-time of 26.88 min was determined for the canine brain. Radiation doses for man were calculated from tissue distribution data for mice.