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Myocardial Imaging in Man with I-123 Meta-Iodobenzylguanidine

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: Robert C. Kline, MD, Div. of Nuclear Medicine, Univ. of Michigan Medical Ctr., 1045 E. Ann St., Ann Arbor, MI 48109.

ABSTRACT

Meta-[¹²³I]iodobenzylguanidine (m-[¹²³I]IBG), a guanethidine analog, was used to image the myocardium in five normal male volunteers. Each subject received 2.0 mCi m-[¹²³I]IBG intravenously. Four were given a bolus injection. Multiple myocardial scintigrams were obtained over a 2-hr period. Myocardial uptake was calculated by dividing the decay-corrected global myocardial count rate (after interpolated background correction) by the peak count rate during the first passage of the m-[¹²³I]IBG bolus through the heart. The left ventricle could be visualized within 1–2 min of m-[¹²³I]IBG injection. Mean myocardial uptake was 0.63% (range 0.45–0.78%) of injected dose at 5 min and 0.76% (range 0.49–0.93%) at 2 hr (n = 4). m-[¹²³I]IBG may provide quantitative information on myocardial catecholamine content.

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