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The Johns Hopkins Medical Institutions, Baltimore, Maryland
Correspondence: For reprints contact: Norman D. LaFrance, MD, Nuclear Medicine, John Hopkins Medical Institutions, 615 N. Wolfe Street, Baltimore, MD 21205.
ABSTRACT
Four out of four patients with brain tumors were observed to have impaired N-isopropyl-p-[123I]iodoamphetamine (IAMPH) accumulation by the lesions even though brain scans with technetium-99m diethylenetriamine pentaacetic acid were normal in two. IAMPH may be a more sensitive means of detecting regional cerebral disease than tracers primarily sensitive to blood-flow abnormalities or impairment of the blood-brain barrier.
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