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Myocardial Imaging with 9-[Te-123m] Telluraheptadecanoic Acid

Massachusetts General Hospital, Boston, Massachusetts
Oak Ridge National Laboratory and Oak Ridge Associated Universities, Oak Ridge, Tennessee

Correspondence: For reprints contact: D. R. Elmaleh, PhD, Physics Research Department, Massachusetts General Hospital, Boston, MA 02114.

ABSTRACT

The distribution of radioactivity in the myocardium of rats and dogs infarcted by ligation of the left anterior coronary artery has been determined after intravenous injection of 9-[Te-123m]telluraheptadecanoic acid (Te-123m HDA). In rats the normal myocardium concentrated radioactivity (3.7% ± 0.28 injected dose/g) to nearly three times that in the zones of infarction (1.12% ± 0.18 dose/g).The focal defects detected in the gamma-camera images of rats and dogs correspond well with areas of infarction identified in the excised hearts by staining with triphenyltetrazolium chloride. The distribution of radioactivity from Te-123m HDA in dog hearts sectioned at autopsy showed a linear correlation (r = 0.94) with blood flow as determined with scandium-46-labeled microspheres.