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Effects of Chain Length and Tellurium Position on the Myocardial Uptake of Te-123m Fatty Acids

Oak Ridge National Laboratory, Oak Ridge, Tennessee
Texas A&M University, College Station, Texas

Correspondence: For reprints contact: F. F. Knapp, Jr., PhD, Nuclear Medicine Technology Group, Health and Safety Research Div., Oak Ridge National Laboratory, Oak Ridge, TN 37830.

ABSTRACT

A series of Te-123m-labeled fatty acids has been synthesized and studied in rats. In the series of compounds studied, the position of the Te-123m heteroatom was not as important as the total chain length, which dramatically affected the heart uptake. Five minutes after injection, significant heart uptake (1.7–2.3% of injected dose) was observed for agents with C₁₅, C₁₇, and C₂₁ chain lengths, in which Te-123m replaced a methylene group in either the 6, 9, 11, or 17 positions, and the heart-to-blood ratios were high. An important observation was the prolonged retention of radioactivity for at least one hour after injection. In contrast, agents with shorter C₁₃ chain lengths, with Te-123m in either the 6 or the 9 position, exhibited only low heart uptake (0.1–0.3% of injected dose).