JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 22 No. 11 959-965
© 1981 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bigler, R. E.
Right arrow Articles by Gillespie, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bigler, R. E.
Right arrow Articles by Gillespie, J. R.

Compartmental Analysis of the Steady-State Distribution of 15O2 and H2 15O in Total Body

Rodney E. Bigler, Jeffrey A. Kostick* and John R. Gillespie

Memorial Sloan-Kettering Cancer Center and Lehman College, City University of New York, New York, New York

Correspondence: For reprints contact: R. E. Bigler, Biophysics Laboratory, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021.

ABSTRACT

It has been suggested that regional oxygen metabolism may be measured quantitatively by analysis of the steady-state distribution of O-15 (T1/2 = 122 sec). For this analysis we have developed a compartmental model that incorporates corrections due to clearance and recirculation of water of metabolism. The oxygen utilization rate is simply proportional to the local O-15 activity if water of metabolism is not recirculated from other tissues and is not lost to the circulation for a time long compared with the half-life of O-15. We evaluated the magnitude of biological metabolic water loss and uptake in the steady state. Our analysis indicates that the magnitude of these effects for rapidly exchanging tissues (such as cerebral gray and white matter), may preclude a simple, noninvasive, and quantitative determination of regional oxygen metabolism. Slowly exchanging compartments, however (such as skeletal muscle and perhaps some tumors), appear amenable to correction for clearance and recirculation effects with sufficient accuracy to make determinations of regional oxygen metabolism feasible.

FOOTNOTES

* Present address: Data General Corporation, MS/A121, 4400 Computer Drive, Westboro, MA 01580.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1981 by the Society of Nuclear Medicine.