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Assessment of Drugs by Functional Imaging of Thallium-201 Distribution in the Dog

Centre Jean Perrin and Unité 195 INSERM, Université Clermont-Ferrand, Clermont-Ferrand, France

Correspondence: For reprints contact: J. Maublant, Centre Jean Perrin, 63011 Clermont-Ferrand, France.

ABSTRACT

The effect of drugs on thallium-201 biodistribution in the body has been studied in dogs using a new functional imaging method. The calculation is based upon the comparison of the activities of the two scintigraphic images obtained after two successive injections of thallium-201 separated by an interval of at least 10 min, during which some drug of interest can be administered. This imaging technique was applied in control dogs (n = 6) and in animals treated with dipyridamole (n = 7) or grisorixin (n = 7). As expected, these two vasoactive drugs increased mainly the myocardial uptake, whereas smaller variations were noted in the other organs studied: liver, kidney, lungs, and skeletal muscles.

Thus this method should allow a rapid and reliable noninvasive assessment of cardiovascular drugs with thallium-201.